Obesity and Diabetes: Energy Regulation by Free Fatty Acid Receptors

Obesity and Diabetes: Energy Regulation by Free Fatty Acid Receptors

Author: Ikuo Kimura

Publisher: Frontiers Media SA

ISBN: 9782889197477

Category: Diseases of the endocrine glands. Clinical endocrinology

Page: 47

View: 541

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Food intake regulates energy balance and its dysregulation leads to metabolic disorder, such as obesity and diabetes. During feeding, free fatty acids (FFAs) are not only essential nutrients but also act as signaling molecules in various cellular processes. Recently, several orphan G protein-coupled receptors (GPCRs) that act as FFA receptors (FFARs) have been identified; GPR40/FFAR1, GPR119, and GPR120 are activated by medium- and long-chain FFAs. GPR84 is activated by medium-chain FFAs. GPR41/FFAR3 and GPR43/FFAR2 are activated by short-chain FFAs. These FFARs have come to be regarded as new drug targets for metabolic disorder such as obesity and type 2 diabetes, because a number of pharmacological and physiological studies have shown that these receptors are primarily involved in the energy metabolism in various tissues; insulin secretion, gastrointestinal hormone secretion, adipokine secretion, regulation of inflammation, regulation of autonomic nervous system, relation to gut microbiota, and so on. This Research Topic provides a comprehensive overview of the energy regulation by free fatty acid receptors and a new prospect for treatment of metabolic disorder such as obesity and type 2 diabetes.
Obesity and Diabetes: Energy Regulation by Free Fatty Acid Receptors
Language: en
Pages: 47
Authors: Ikuo Kimura, Atsuhiko Ichimura
Categories: Diseases of the endocrine glands. Clinical endocrinology
Type: BOOK - Published: 2016-02-03 - Publisher: Frontiers Media SA

Food intake regulates energy balance and its dysregulation leads to metabolic disorder, such as obesity and diabetes. During feeding, free fatty acids (FFAs) are not only essential nutrients but also act as signaling molecules in various cellular processes. Recently, several orphan G protein-coupled receptors (GPCRs) that act as FFA receptors
Free Fatty Acid Receptors
Language: en
Pages: 256
Authors: Graeme Milligan, Ikuo Kimura
Categories: Medical
Type: BOOK - Published: 2017-02-08 - Publisher: Springer

This book highlights the important role free fatty acids (FFA) play as potential drug targets. While FFA have long been considered byproducts of cell metabolism, they are now recognized as ligands that regulate cell and tissue function via G-protein-coupled receptors. At least three receptors have been identified for which FFA
Free Fatty Acid Receptors
Language: en
Pages: 256
Authors: Graeme Milligan, Ikuo Kimura
Categories: Medical
Type: BOOK - Published: 2018-07-13 - Publisher: Springer

This book highlights the important role free fatty acids (FFA) play as potential drug targets. While FFA have long been considered byproducts of cell metabolism, they are now recognized as ligands that regulate cell and tissue function via G-protein-coupled receptors. At least three receptors have been identified for which FFA
Agonist-receptor Interactions Involved with Mobilization of Free Fatty Acids from Adipose Tissue
Language: en
Pages: 184
Authors: Dennis R. Feller
Categories: Adipose tissues
Type: BOOK - Published: 1968 - Publisher:

Books about Agonist-receptor Interactions Involved with Mobilization of Free Fatty Acids from Adipose Tissue
Free Fatty Acid Receptor 2
Language: en
Pages: 0
Authors: Simon Lind
Categories: Adipose tissues
Type: BOOK - Published: 2022 - Publisher:

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