Herpesviruses, the Immune System, and AIDS

Herpesviruses, the Immune System, and AIDS

Author: Yechiel Becker

Publisher: Springer

ISBN: 9780792308034

Category: Medical

Page: 377

View: 788

Download BOOK »

Shortly after the reeognition of the aequired immunodefieieney syndrome (AIDS) in 1981 (1-3), it was hypothesized that herpesviruses may play an important role in the etiology or pathogenesis of this newly identified syndrome (4,5). This theory was based on the faet that infeetion with herpesviruses was a prominent elinieal feature in nearly all patients with AIDS (3-5). Chronie mueocutaneous herpes simplex virus (HSV) infections were one of the first opportunistie infeetions deseribed in patients with AIDS (3), and both cytomegalovirus (CMV) and HSV infections were extremely common in individuals identified to be at highest risk for aequiring AIDS, such as homosexual men, intravenous drug users and hemophiliaes (4-8). CMVand Epstein-Barr virus (EBV) were also prominent infeetions whieh were suspected as possible etiologic agents of the prolonged fever, wasting, and Iymphadenopathy that often precedes AIDS, frequently referred to as the chronie Iymphadenopathy syndrome (9,10). Subsequent elinieal studies have indeed demonstrated that infeetions with HSV, CMV, EBV, and even varieella zoster virus (VZV) are frequent opportunistic infeetions wh ich oeeur among AIDS patients (11-14). Several of the opportunistie infeetions caused by herpesviruses include encephalitis, chorioretinitis, hairy leukoplakia, esophagitis, enteritis, colitis, Burkitt's lymphoma, primary CNS lymphoma, zoster, and there has even been speculation about the role of CMV in the pathogenesis of Kaposi's sareoma (15,16). Furthermore, the herpesviruses, partieularly CMV and EBV have been known to be strongly associated with immunosuppression, partieularly of cell-mediated immune functions, which further supported the hypothesis that herpesviruses may contribute to the immune defects that eharacterize AIDS.
Herpesviruses, the Immune System, and AIDS
Language: en
Pages: 377
Authors: Yechiel Becker
Categories: Medical
Type: BOOK - Published: 1990-07-31 - Publisher: Springer

Shortly after the reeognition of the aequired immunodefieieney syndrome (AIDS) in 1981 (1-3), it was hypothesized that herpesviruses may play an important role in the etiology or pathogenesis of this newly identified syndrome (4,5). This theory was based on the faet that infeetion with herpesviruses was a prominent elinieal feature
Herpesviruses, the Immune System, and AIDS
Language: en
Pages: 377
Authors: Yechiel Becker
Categories: Medical
Type: BOOK - Published: 2012-12-06 - Publisher: Springer Science & Business Media

Books about Herpesviruses, the Immune System, and AIDS
HIV/AIDS in the Post-HAART Era
Language: en
Pages: 1052
Authors: John C. Hall, Brian John Hall, Clay J. Cockerell
Categories: Medical
Type: BOOK - Published: 2011 - Publisher: PMPH-USA

The science of the virus and its effects and the clinical approaches to its treatment and transmission prevention are placed in the context of the history and epidemiology of the HIV-AIDS pandemic. Each organ system of the body is explored as to manifestations of the disease, treatment now and in
A Holistic Protocol for the Immune System
Language: en
Pages: 88
Authors: Scott J. Gregory
Categories: AIDS (Disease)
Type: BOOK - Published: 1992 - Publisher: Progressive Press

Books about A Holistic Protocol for the Immune System
Humanized Mice for HIV Research
Language: en
Pages: 538
Authors: Larisa Y. Poluektova, J. Victor Garcia, Yoshio Koyanagi, Markus G. Manz, Andrew M. Tager
Categories: Medical
Type: BOOK - Published: 2015-02-18 - Publisher: Springer

Over the last several years the field of humanized mice has matured and developed into an essential component of translational research for HIV/AIDS. Humanized mice serve both as vehicles for discovery and as highly sophisticated platforms for biomedical research. In addition, humanized mice have demonstrated outstanding potential for the investigation