Microbial DNA and Host Immunity

Microbial DNA and Host Immunity

Author: Eyal Raz

Publisher: Springer Science & Business Media

ISBN: 9781592593057

Category: Science

Page: 408

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Leading researchers review the activation of the mammalian immune system by bacterial DNA and its immunostimulatory sequences (ISS), and consider the applications of ISS in clinical medicine. The authors survey the latest findings concerning the receptor-recognition and signaling pathways triggered by ISS , the process of cell activation, and the potential vaccination strategies using ISS. Specific pharmaceutical applications discussed include infectious disease (Hepatitis B, HIV, and mycobacterial infections), allergy (asthma and conjunctivitis), cancer (lymphoma), and inflammation and autoimmunity (arthritis and colitis).
Microbial DNA and Host Immunity
Language: en
Pages: 408
Authors: Eyal Raz
Categories: Science
Type: BOOK - Published: 2002-09-26 - Publisher: Springer Science & Business Media

Leading researchers review the activation of the mammalian immune system by bacterial DNA and its immunostimulatory sequences (ISS), and consider the applications of ISS in clinical medicine. The authors survey the latest findings concerning the receptor-recognition and signaling pathways triggered by ISS , the process of cell activation, and the
Microbial DNA and Host Immunity
Language: en
Pages: 428
Authors: Eyal Raz
Categories: Science
Type: BOOK - Published: 2002-09-26 - Publisher:

The immunostimulatory prospects of bacterial DNA have attracted the interest and attention of scientists and physicians and become a major focus in immunobiology and biomedicine. These activities are the product of immunostimulatory DNA sequences (ISS, also known as GpG motifs), which are rare in the mammalian genome. ISS were shown
Biological DNA Sensor
Language: en
Pages: 368
Authors: Søren R. Paludan, Andrew G. Bowie
Categories: Medical
Type: BOOK - Published: 2013-10-30 - Publisher: Elsevier Inc. Chapters

Microbial and host DNA are potent stimulators of innate immune responses and have been implicated in both host defense and autoimmune diseases. To date more than 10 immunological sensors of DNA have been proposed, and we are now beginning to understand the functions and mechanism of action of these proposed
Understanding and Exploiting Host-Commensal Interactions to Combat Pathogens
Language: en
Pages:
Authors: Sudhanshu Shekhar, Fernanda Cristina Petersen, Xi Yang
Categories: Medical
Type: BOOK - Published: 2020-01-14 - Publisher: Frontiers Media SA

Trillions of commensal microbes reside on and inside the human body, including the intestinal and respiratory tracts, which encompass various microbial taxa, such as bacteria, fungi, archea and viruses. The close proximity of microbes with the host provides an opportunity to continually interact with each other. Advances in research approaches,
Bugs as Drugs
Language: en
Pages: 514
Authors: Robert A. Britton, Patrice D. Cani
Categories: Medical
Type: BOOK - Published: 2020-07-02 - Publisher: John Wiley & Sons

Examining the enormous potential of microbiome manipulation to improve health Associations between the composition of the intestinal microbiome and many human diseases, including inflammatory bowel disease, cardiovascular disease, metabolic disorders, and cancer, have been elegantly described in the past decade. Now, whole-genome sequencing, bioinformatics, and precision gene-editing techniques are being