Microbial DNA and Host Immunity

Microbial DNA and Host Immunity

Author: Eyal Raz

Publisher: Springer Science & Business Media

ISBN: 9781592593057

Category: Science

Page: 408

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Leading researchers review the activation of the mammalian immune system by bacterial DNA and its immunostimulatory sequences (ISS), and consider the applications of ISS in clinical medicine. The authors survey the latest findings concerning the receptor-recognition and signaling pathways triggered by ISS , the process of cell activation, and the potential vaccination strategies using ISS. Specific pharmaceutical applications discussed include infectious disease (Hepatitis B, HIV, and mycobacterial infections), allergy (asthma and conjunctivitis), cancer (lymphoma), and inflammation and autoimmunity (arthritis and colitis).
Microbial DNA and Host Immunity
Language: en
Pages: 408
Authors: Eyal Raz
Categories: Science
Type: BOOK - Published: 2002-09-26 - Publisher: Springer Science & Business Media

Leading researchers review the activation of the mammalian immune system by bacterial DNA and its immunostimulatory sequences (ISS), and consider the applications of ISS in clinical medicine. The authors survey the latest findings concerning the receptor-recognition and signaling pathways triggered by ISS , the process of cell activation, and the
Microbial DNA and Host Immunity
Language: en
Pages: 428
Authors: Eyal Raz
Categories: Science
Type: BOOK - Published: 2002-09-26 - Publisher:

The immunostimulatory prospects of bacterial DNA have attracted the interest and attention of scientists and physicians and become a major focus in immunobiology and biomedicine. These activities are the product of immunostimulatory DNA sequences (ISS, also known as GpG motifs), which are rare in the mammalian genome. ISS were shown
Biological DNA Sensor
Language: en
Pages: 368
Authors: Søren R. Paludan, Andrew G. Bowie
Categories: Medical
Type: BOOK - Published: 2013-10-30 - Publisher: Elsevier Inc. Chapters

Microbial and host DNA are potent stimulators of innate immune responses and have been implicated in both host defense and autoimmune diseases. To date more than 10 immunological sensors of DNA have been proposed, and we are now beginning to understand the functions and mechanism of action of these proposed
Understanding and Exploiting Host-Commensal Interactions to Combat Pathogens
Language: en
Pages: 195
Authors: Sudhanshu Shekhar, Fernanda Cristina Petersen, Xi Yang
Categories: Medical
Type: BOOK - Published: 2020-01-14 - Publisher: Frontiers Media SA

Trillions of commensal microbes reside on and inside the human body, including the intestinal and respiratory tracts, which encompass various microbial taxa, such as bacteria, fungi, archea and viruses. The close proximity of microbes with the host provides an opportunity to continually interact with each other. Advances in research approaches,
Medical Microbiology,With STUDENTCONSULT online access,18
Language: en
Pages: 778
Authors: David Greenwood
Categories: Medical
Type: BOOK - Published: 2012 - Publisher: Elsevier Health Sciences

Medical microbiology concerns the nature, distribution and activities of microbes and how they impact on health and wellbeing, most particularly as agents of infection. Infections remain a major global cause of mortality and in most hospitals around one in ten of those admitted will suffer from an infection acquired during